ubiquinone

Well I have been taking some drugs for a while:

• Mycardis for high blood pressure and
• Simvastatin for high cholesterol.
  

The Mycadis is helping but not enough. The Simvastation has done the trick. Today my chemist suggested that I also try ubiquinone. So, as I have a high respect for his knowledge I purchased some. That respect did not stop me from researching the topic. It sounds like a good choice:

There are several reports concerning the effect of CoQ₁₀ on blood pressure in human studies (for review: ^[19]). In a recent meta-analysis of the clinical trials of CoQ₁₀ for hypertension a research group led by Professor FL Rosenfeldt (from the Cardiac Surgical Research Unit, Alfred Hospital, Melbourne, Australia) reviewed all published trials of Coenzyme Q₁₀ for hypertension, assessed overall efficacy and consistency of therapeutic action and side effect incidence. Meta-analysis was performed in 12 clinical trials (362 patients) comprising three randomized controlled trials, one crossover study and eight open label studies. The research group concluded that coenzyme Q₁₀ has the potential in hypertensive patients to lower systolic blood pressure by up to 17 mm Hg and diastolic blood pressure by up to 10 mm Hg without significant side effects. ^[20]

Coenzyme Q₁₀ shares a common biosynthetic pathway with cholesterol. The synthesis of an intermediary precursor of Coenzyme Q₁₀, mevalonate, is inhibited by some beta blockers, blood pressure lowering medication,^[21] and statins, a class of cholesterol lowering drugs.^[22] Statins can reduce serum levels of coenzyme Q₁₀^[23] Some research suggests the logical option of supplementation with coenzyme Q₁₀ as a routine adjunct to any treatment which may reduce endogenous production of coenzyme Q₁₀, based on a balance of likely benefit against very small risk.^[24][25] by up to 40%.